Although FLT3 receptor levels were similar between the FTL3-WT and FLT3-ITD AML groups, FLT3-ITD expressing samples displayed attenuated responses to FLT3L, as measured by induced levels of p-S6, p-Erk, p-Akt and p-CREB versus their FLT3-WT counterparts (Tables 4, S3, S4 and Figure S4). Here, CREB1 is linked to acute myeloid leukemia.