FLT3 and acute myeloid leukemia: Signaling profiles were assessed in samples from two groups of Cytogenetically Normal (CN) AML patients, each representing a clinically extreme example of an “outlier” (based on the molecular characterization): 1) FLT3-WT AML who experienced disease relapse within three months after initial remission and 2) FLT3-ITD AML in complete continuous disease remission for two or more years.