SNCA and Lewy body dementia: However, a combination of CSF measures appear to emerge,that may well be able to differentiate DLB from other dementias: α-synucleinreduction in early DLB, a correlation between CSF α-synuclein and Aβ42 measures(characteristic for DLB only), and t-tau and p-tau181 profile (differentiating AD fromDLB).