CASP3 and aplastic anemia: Caspase-3 activity showed by BM-HSCs in Aplastic anemia (49%) was significantly higher compared to that of the normal control (2.6%) (Figure 3), further confirming the fact that the bone marrow HSCs undergo premature apoptosis in Aplastic anemia, ultimately resulting in marked decrease in the primitive Sca1+ population which have already been confirmed by Flowcytometric analysis.