Thus we conclude that the genes conserved between mouse and human, found in the most telomeric part of Hsa21, and trisomic in Tc1, are not contributing to the major Tc1 phenotypes, suggesting that the Cstb–Prmt2 region is not playing a major role in locomotor and cognitive deficits found in DS. The gene discussed is PRMT2; the disease is Cognitive impairment.