TH1 cytokines are generally up-regulated in patients with HCC, resulting in higher levels of pro-inflammatory cytokines, as IL-1β, IL-15, IL-18, TNF-α, TNF-αRs, TNF-αRI, TNF-αRII, and IL-6 in comparison with healthy individuals [49]. The gene discussed is IL6; the disease is hepatocellular carcinoma.