Preliminary data showed that pro-inflammatory molecules (IL-1α, IL-6, IL-8, IL-12p40, GM-CSF, CCL27, CXCL1, CXCL9, CXCL10, CXCL12, β-NGF) resulted significantly up-regulated in patients affected by HCC with chronic HCV-related hepatitis and liver cirrhosis [52]. This evidence concerns the gene CXCL8 and hepatocellular carcinoma.