PTGS2 and hepatocellular carcinoma: Recent evidence suggested that cyclooxygenase-2 (COX-2)-derived prostaglandin PGE(2) and Wnt/beta-catenin signaling pathways are implicated in hepatocarcinogenesis and reported that omega-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) inhibited HCC growth through simultaneously inhibition of COX-2 and beta-catenin [74].