POU2F3 and heart failure: Consistent with our in vitro experiments and large studies that have examined the role of platelet receptor polymorphisms in thrombosis, immune disease and intravascular device infection, GPIIIa PlA1/A2 and FcγRIIa H131R genotype did not influence the development of infective endocarditis, vegetation characteristics or the composite clinical end-point of embolism, heart failure, need for surgery or mortality [16,34–36].