Nevertheless, the combination of approaches employed here, including the analysis of samples from well-defined clinical cases of infective endocarditis and in vitro platelet functional analyses, strongly suggest that the GPIIIa PlA1/A2 and FcγRIIa H131R platelet receptor polymorphisms do not influence S. aureus–platelet interactions in vitro and do not constitute risk factors for infective endocarditis. Here, POU2F3 is linked to infective endocarditis.