Taken together, the ability of LPA to function as a survival factor in ovarian cancer cells, the ability of RGS proteins to suppress LPA stimulated G-protein activity, and the differential expression of RGS proteins in ovarian cancer cells suggest that changes in RGS expression levels during ovarian cancer progression may regulate the strength of LPA mediated survival signals and contribute to chemoresistance. Here, PITX2 is linked to ovarian cancer.