SEMA4A and metabolic dysfunction-associated steatohepatitis: We also show, for the first time, that a large number of plexin/semaphorin family members (28 members) are expressed in the human liver and that the expression of the “immune semaphorins” (SEMA4A, SEMA7A, SEMA4D, and PLXNC1) is upregulated in NASH patients.