The 72-year-old mother (I.2, Fig. 1A) had a history of severe uncontrolled arterial hypertension and hypokalemia (Table 1), with no clinical features of hypercortisolism or hyperandrogenism (testosterone 0.31 ng/mL, N 0.1-0.4, D4-androstenedione 1.3 ng/mL, N 0.6-1.6, DHEAS 400 ng/ml, N 200-2300). This evidence concerns the gene SULT2A1 and Hypertension.