In particular, mutations in several genes for transcription factors including the homeobox genes, PAX6 (11q), FOXE3 (1q), PITX3 (10q) and VSX2 (14q), and the bZIP transcription factor V-MAF avian musculo-aponeurotic fibrosarcoma oncogene homolog (MAF, 16q) underlie cataract plus anterior segment developmental disorders and microphthalmia sometimes associated with secondary glaucoma [41]. Here, PITX3 is linked to microphthalmia.