Of note, total forms of the AMPK pathway proteins do not show substantial differences between MLL-rearranged and non-translocated patients (Figure 2B), corroborating the observation that the higher phosphorylation levels of the proteins in the AMPK pathway are the peculiar molecular derangement characteristic of MLL-rearranged BCP-ALL. Here, KMT2A is linked to acute lymphoblastic leukemia.