CASP3 and Huntington disease: One important feature of HD pathology is the elevation of caspase-3/7 activity.  When we measure caspase-3/7 activity of the HD-NSCs and wild-type NSCs (WT-NSCs from normal iPS or H9 ESCs) 24 hours after withdrawal of growth factors, the HD-NSCs but not WT-NSCs showed enhanced caspase activity.