Considering lymph node metastasis, Marioni et al. [36], in an evaluation of 13 consecutive cases of oral and oropharyngeal SCC with pN+ and 13 cases of pN0, demonstrated that eight patients in the pN+ group were survivin-positive (mean expression 34.7%), compared to five in the pN0 group (12.3%), and this difference was statistically significant (P = 0.017). The gene discussed is BIRC5; the disease is metastatic malignant neoplasm in the lymph nodes.