Patients with OPN concentrations greater than the median value had a higher incidence of CAD than those with OPN levels below the medium value (80.8% vs. 69.3%, respectively; P < 0.05), but differences were not found for patient groups stratified according to N-half OPN values (76.2% vs. 74.0%; P > 0.05; Table 2). This evidence concerns the gene SPP1 and coronary artery disorder.