ADAM12 and trisomy 21: Median ADAM12-S MoM values for trisomy 21 pregnancies in these studies are largely inconsistent with the initial findings of Laigaard et. al., and show a moderate to negligible reduction relative to unaffected MoM values; ranging from 0.61 MoM [16] among samples collected before 10 weeks gestation, to 0.977 MoM [15] between 11 and 13 weeks gestation.