The highest cancer frequency was recorded in the following groups: HEC/g1 (41.5%, 95% CI: 27.8 - 56.6%), the whole hereditary and familial endometrial cancer group (41.0%, 95% CI: 36.1 - 46.2%), HNPPC/g1 (30.1%, 95% CI: 23.3 - 38.0%), FLC/g1 (25.5%, 95% CI: 19.3 - 32.8%) and HGC/g1 (25.2%, 95% CI: 20.6 - 30.4%). This evidence concerns the gene NDC80 and cancer.