TARDBP and early-onset autosomal dominant Alzheimer disease: Recently, TDP-43 has also been found as the major protein component of the intracellular inclusions occurring in the neuronal tissues of patients affected by a series of neurodegenerative diseases which include Fronto Temporal Lobar Degeneration (FTLD-U), Amyotrophic Lateral Sclerosis (ALS) (Geser et al., 2009; Neumann et al., 2006) and in a significant proportion of Alzheimer Disease patients (Amador-Ortiz et al., 2007; Bigio, 2008; Rohn, 2008).