For a detailed clinical view of TARDBP mutation carriers in the aforementioned diseases the reader is referred to the Alzheimer Disease and Frontotemporal Dementia Mutation Database (http://www.molgen.ua.ac.be/ftdmutations) and to the Amyotrophic Lateral Sclerosis Online genetic Database (http://alsod.iop.kcl.ac.uk). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.