NF1 and plexiform neurofibroma: However, although there is some disparity in different studies, reports using different methodologies, such us comparative genomic hybridisztion (CGH) [Mechtersheimer et al., 1999], cytogenetic karyotyping of dermal neurofibroma-derived Schwann cells [Wallace et al., 2000], cytogenetic karyotyping of short term neurofibroma cultures [Mertens et al., 2000], array-CGH [Mantripragada et al., 2008, 2009], Eric Legius, personal communication), and SNP-array analyses (Nancy Ratner and the NF1 Microarray Consortium, unpublished results), indicated a paucity of recurrent gross alterations in dNFs.