Polymorphisms in genes encoding PPAR-γ,[11] eNOS,[12] GLUT-1,[13] aldose reductase,[14] MTHFR,[15] apo-E[16] and components of the renin-angiotensin system (RAS) including angiotensinogen, Ang-II receptor type 1,[17] and particularly, the ACE gene,[18] have been implicated in the pathogenesis of diabetic nephropathy. Here, ACE is linked to diabetic kidney disease.