In addition, the study reported that the estimated frequency for the HLA-DRB1*0407- HLA-DQB1*0302 haplotype in the POAG patients was 25.9%, much higher than the 15.4% frequency reported for the HLA-DRB1*0407 allele in the patients. This evidence concerns the gene HLA-DRB1 and open-angle glaucoma.