APOE and age-related macular degeneration: Although AMD has been reported to be associated with genetic variations in the genes of adenosine-triphosphate (ATP)-binding transporter protein 4 [44-46], apolipoprotein E [47-52], excision-repair cross-complementing group 6 [53], fibulin 5 [54], fibulin 6 [55,56], elongation of very-long-chain fatty acids-like 4 [57-59], factor B/complement component 2 [60], toll-like receptor 4 [61-63], and vascular endothelial growth factor [64], recent genome-wide linkage studies found that genomic regions at chromosomes 1q31–32 and 10q26 may have a bigger role in susceptibility to AMD [65].