Three genes identified at chromosome 10q26 and associated with the risk of AMD are Pleckstrin Homology Domain-containing Protein Family A member 1, age-related maculopathy susceptibility 2 (LOC387715/age-related maculopathy susceptibility 2 [ARMS2]), and high-temperature requirement factor A1 (HTRA1/PRSS11) [65,76,82-84]. The gene discussed is ARMS2; the disease is age-related macular degeneration.