HTRA1 and age-related macular degeneration: A single-nucleotide polymorphism (rs11200638) in the promoter region of the HTRA1 gene was found to be significantly associated with susceptibility to AMD in studies of Caucasian populations in the US [90-97], Central Europe [98], France [99], and the UK [100]; of East Asian populations in China [101-104] and Japan [105-107]; and of Indian populations in India [108].