HTRA1 and age-related macular degeneration: Although an association between the HTRA1rs11200638 G→A polymorphism and AMD was found, Kanda and others [95] considered that the rs11200638 G→A polymorphism of the HTRA1 gene did not make a major contribution to regulation of the HTRA1 gene and there is no association between HTRA1 G→A polymorphism and AMD.