LTA C+80A (rs2239704), a SNP that allows specific binding of the transcriptional repressor ABF-1 and, therefore, considered to be a low LTα-producing allele, has been associated with lower P. falciparum parasitaemia in malaria-endemic Burkina Faso but was not associated with SM in a case-control study in The Gambia [40,51,52]. The gene discussed is MSC; the disease is systemic mastocytosis.