Some studies have found that the Met allele of the COMT Val158Met is associated with increased ADHD symptom severity in children [75], girls with ADHD were more likely than boys to have the predominantly inattentive type of ADHD [76], anxiety in women [77] and with lower extraversion personality and neuroticism among healthy adults of both genders [78]. The gene discussed is COMT; the disease is attention deficit-hyperactivity disorder.