One emerging view that clarifies the paradoxical role of RUNX2 in cancer cells is that this factor may promote tumorigenesis by enhancing the expression of genes linked to metastatic properties (for example, cell motility and invasion) and/or angiogenesis once cells have succeeded in bypassing RUNX2 dependent growth restrictions [5-7,11-15,20-22,24-27,31,61,66]. This evidence concerns the gene RUNX2 and cancer.