SOD1 and Alzheimer disease: Accordingly, there was a difference between 3xTg-AD sedentary males and females in SOD-Mn (P < .05), GSH (P < .001), GSSG (P < .001), and GPx (P < .05), but in exercised male and female 3xTg-AD the difference was only observed for GSH (P < .001), GSSG (P < .001), and GPx (P < .001).