MAPT and Alzheimer disease: This study evaluates the effects of just 5 weeks of treadmill exercise on the brain and peripheral organ function of 3xTg-AD mice at several levels of study, namely the cellular (oxidative stress), neurochemical (GABA function), physiological (body weight curve, glucose homeostasis), immunoendocrine (involution of thymus, plasma levels of glucocorticoids), behavioral (BPSD-like and cognition impairments), and neuropathological (presence of amyloid and tau pathologies).