Alternatively, many other proteins have been evaluated as potential targets for tumor immunotherapy including tissue differentiation antigens such as tyrosinase, Melan A/Mart-1, gp 100, and prostatic acid phosphatase (PAP) or antigens expressed at low levels in normal tissues and high levels in tumor tissue such as HER2 and Muc 1, [11–13]. This evidence concerns the gene TYR and neoplasm.