In a report by Güre et al. it was found that SSX4 was inducible with the histone deacetylase inhibitor Trichostatin A (TSA) in melanoma cell lines, with minor effects for SSX2 and SSX6, whereas 5-aza-dc was able to more effectively induce expression of SSX1, 2, 4, and 5 in melanoma cell lines [29]. This evidence concerns the gene SSX4 and melanoma.