They report that SSX2IP was identified as a leukemia antigen through a SEREX screen, specifically recognized in the sera of patients with acute myeloid leukemia (AML) as compared to sera from healthy donors, and that SSX2IP expression was found in 33% of leukemic cells from AML patients but not in normal donor hematopoietic cells tested by RT-PCR [56]. The gene discussed is SSX2IP; the disease is leukemia.