They tested ST2825 in experimental animal models of autoimmune, and inflammatory diseases, such as lupus, inflammatory bowel disease, and multiple sclerosis, and found that ST2825 could interfere with the recruitment of IRAK1 and IRAK4 by MyD88, resulting in the inhibition of IL-1β-mediated activation of NF-κB and IL-6. The gene discussed is IRAK1; the disease is systemic lupus erythematosus.