VEGF is one of the principal factors in angiogenesis.[10] VEGF is increased in bladder tumor and this increase is influenced by tumor stage and grade.[23, 24] VEGF also has an effect on prognosis and recurrence of bladder tumor.[25] This study was designed to assess the changes of VEGF level in serum and urine after BCG therapy. The gene discussed is VEGFA; the disease is urinary bladder neoplasm.