On the other hand, many studies have shown the role of angiogenesis in tumor progression and spread.[7–9] Many factors are included in angiogenesis among which vascular endothelial growth factor (VEGF) seems to be one of the most important components.[10, 11] VEGF is a principal regulator of angiogenesis, which induces proliferation and differentiation of endothelial cells. The gene discussed is VEGFA; the disease is neoplasm.