CD4 and AIDS: There is conflicting data regarding the incidence of lung carcinoma in AIDS and, to date, there is no convincing evidence showing a significant rise.[56, 58, 62] It occurs in smokers, although important clinical differences have been noted compared with the general population.[58] There is a striking male preponderance and patients often present at a younger age and at a later stage.[58, 62] There is no correlation between stage of disease and CD4 count.