However, the present study has been conducted using T-ALL cell lines without MLL-translocations and provides evidence that in the absence of such translocations cellular GC sensitivity is related to the level of expression of wild-type MLL. One interpretation of this data is that alterations in MLL support the proliferative phenotype that we have previously associated with GC resistance [11]. Here, KMT2A is linked to acute lymphoblastic leukemia.