EPHB1 and melanoma: As determined by quantitative real-time RT-PCR, the gene expression of ephrin B1 in lumbar (L) 4-5 DRGs was induced 1.8 fold in cancer-induced pain mice compared to normal control mice on day 15 after melanoma transplantation (p < 0.001) (Figure 1A); however, no change was observed for the Eph B1 receptor (Figure 1B).