The level of phosphorylated Tyr-1472 NR2B in the vehicle control in cancer-induced pain mice was 210% higher than the normal control samples (p < 0.05) (Figure 3A, B); however, the repeated administration of Z-360 (100 mg/kg) once a day from day 7 to 14 after transplantation suppressed phosphorylation by 62.5% compared with the vehicle control (p < 0.05) (Figure 3A, B). Here, GRIN2B is linked to cancer.