Chronic gastritis and gastric ulcer are part of the natural evolution to stomach cancer [3,4], and it is possible that a similar phenomenon occurs in Mexico as has been observed in Asian populations, in which the distribution of IL-1B genotypes differs between the northern region, where there is a high prevalence of stomach cancer, and the southern region, where there is a low prevalence of stomach cancer [33-35,43]. Here, IL1B is linked to gastric neoplasm.