Although no statistically significant association was found with tumor location (P = 0.249), BRAF mutations were observed more frequently in proximal than in distal carcinomas, which is in agreement with previous studies reporting that BRAF mutations occur more frequently in carcinomas arising in the right colon (17.8% versus 3.6% in rectal carcinomas) [13,17]. Here, BRAF is linked to carcinoma.