Mutations in the MSI target genes IGF2R and BAX were found in one (33.3%) and two (66.7%) out of the three rectal MSI-H carcinomas, respectively (Figure 1; Table 1), whereas no mutations were detected in TGFBR2, MSH3, and MSH6 microsatellite sequences in this test series. This evidence concerns the gene IGF2R and carcinoma.