BRAF and rectal carcinoma: Several articles found an association between BRAF mutations (namely V600E) and the MSI-H phenotype caused by MLH1 gene promoter hypermethylation (frequently in the right colon), but the sigmoid and rectal carcinoma in our test and validation series, respectively, with BRAF mutation were MSI-H and did not present MLH1 promoter hypermethylation [37,38].