SPP1 and osteosarcoma: In a study comparing the gene expression of 22 human osteosarcoma tumors to 5 normal human osteoblasts, osteosarcoma tumors had increased expression of RECQL4, SPP1, RUNX2, and IBSP and decreased DOCK5, CDKN1A, RB1, P53, AND LSAMP compared to normal osteoblasts.