Conversely, previous work has indicated the involvement of various gene mutations with prognostic relevance in AML, including activating mutations of genes encoding transcription factors (AML1, CEBPα), tyrosine kinases (FLT3, KIT) or their downstream effectors (NRAS) and nucleophosmin (NPM1) mutations [3,5]. Here, NPM1 is linked to acute myeloid leukemia.