Conversely, previous work has indicated the involvement of various gene mutations with prognostic relevance in AML, including activating mutations of genes encoding transcription factors (AML1, CEBPα), tyrosine kinases (FLT3, KIT) or their downstream effectors (NRAS) and nucleophosmin (NPM1) mutations [3,5]. Here, FLT3 is linked to acute myeloid leukemia.