KLK3 and cancer: With respect to other cancer types, a pilot study reported that ARBs had cytostatic activity in hormone-refractory prostate cancer, as indicated by decreased prostate-specific antigen levels (Uemura et al, 2005), and the addition of ACEIs/ARBs to platinum-based chemotherapy was associated with prolonged survival in patients with advanced non-small cell lung cancer in a retrospective study (Wilop et al, 2009).