Our cell lines modelled closely the diversity observed in primary medulloblastomas; D384Med cells were proficient for all proteins tested, indicating they reflect the vast majority of primary medulloblastomas, in which MMR deficits (observed in ∼10% of cases; Viana-Pereira et al, 2009) and MGMT hypermethylation (∼25% of cases; Lindsey et al, 2005) are relatively uncommon. The gene discussed is MGMT; the disease is medulloblastoma.