Therefore, the aims of the present study were two-fold: (1) to examine the annual frequency of SSE and CSE practices in a sample of individuals at high risk of developing melanoma due to strong family history and an identified family-specific mutation in the CDKN2A gene; (2) to identify the demographic, clinical and psychosocial factors associated with the uptake of these skin cancer screening behaviours. The gene discussed is CDKN2A; the disease is melanoma.