It has been reported that the homozygocity for the T allele of MTHFR was more frequent in patients with premature myocardial infarction than in controls (27.1% vs. 14.6%, P = 0.02) [30], in CAD patients than in control subjects (28.5% vs. 13.5%, P < 0.00003) [27], and in diabetics than in healthy subjects (12.8% vs. 7.2%) [23]. Here, MTHFR is linked to coronary artery disorder.