Consequently, magnetic beads coated with anti-CD3 and anti-CD28 (anti-CD3/CD28 beads) have proved a convenient reagent for expansion which has been used experimentally to boost T cell immunity in immunosuppressed cancer patients [8-10] and enhance the anti-tumor effect of donor lymphocyte infusions after allotransplantation [11]. The gene discussed is CD28; the disease is cancer.