The upreguation of TAGLN and downregulation of SOX9, IRS1, P15, AREG, IER5L, KRT8 in RKO, SW620 and CW2 colon cancer cells indicated these genes may be the target molecules for the biological behaviour of IGFBP-rP1 in colon cancer. The gene discussed is KRT8; the disease is malignant colon neoplasm.