We found that IGFBP-rP1 could upreguate TAGLN, downregulate SOX9, IRS1, P15, AREG, IER5L, KRT8 in these colon cancer cells(Figure 8), indicating that these genes may be the important IGFBP-rP1 responsible genes in colon cancer. This evidence concerns the gene CDKN2B and colonic neoplasm.