The upreguation of TAGLN and downregulation of SOX9, IRS1, P15, AREG, IER5L, KRT8 in RKO, SW620 and CW2 colon cancer cells indicated these genes may be the target molecules for the biological behaviour of IGFBP-rP1 in colon cancer. Here, SOX9 is linked to malignant colon neoplasm.