In a study by Mohiuddin et al. [11], which reported improvement in symptoms and survival with an additional boost dose to the dominant disease in colorectal cancer multiple liver metastases, Karnofsky performance score ≥ 80 was in 75.6% (34/45) patients and more than half of the patients had normal level of CEA and liver function tests. Here, CEACAM5 is linked to colorectal cancer.