In a recent study, Gomez-Valades et al. [23] partially silenced Pck1 expression by ∼50% in the liver of db/db mice and observed a reduction of fed glycaemia confirming that the downregulation of Pck1 per se in the liver only can be sufficient to improve glycaemia in this model of T2D. The gene discussed is PCK1; the disease is type 2 diabetes mellitus.