Compared to the evaluation of DcR3 protein detection, Wu et al. (8) established an enzyme-linked immunosorbent assay (ELISA) to measure DcR3 serum concentrations in HCC, and 74.3% (26/35) of the patients were found to be DcR3-positive (>20 pg/mL). The gene discussed is TNFRSF6B; the disease is hepatocellular carcinoma.