Interestingly, expression of genes identified as consistently developmentally reduced in expression between WT and DKO mice, Slc11a2 and Lynx1, was similar between AC8 rescue and DKO mice, suggesting that these gene changes are not necessary for intact CF memory as expression levels are not rescued in the AC8 rescue mice while learning deficits are rescued (Fig. 1). The gene discussed is SLC11A2; the disease is cystic fibrosis.