ITGB2 and systemic lupus erythematosus: Importantly, our human SLE gene network analysis and murine validation studies revealed – for the first time – a possible pathogenic role for: a) HSPB1, a co-chaperone that regulates the chaperone Hsp70 and is involved in stress-induced cell migration [28], and b) ITGB2, encoding the β2 integrin family, that was reported to protect against development of autoimmune diabetes in NOD/LtJ mice [29].