Involvement of AKT, NF-κB, HSP90, proteosome, IER3 and HSPB1 as central nodes in the gene network of active patients highlights their importance in SLE since the PI3K/AKT/mTOR signaling pathway plays an important role in the differentiation of peripheral B cells and in T cell homeostasis. This evidence concerns the gene IER3 and systemic lupus erythematosus.