MAPK8 and ovarian carcinoma: We have recently reported that in ovarian cancer cells, 4-HPR-induced apoptosis is mediated by the proapoptotic PLAcental Bone morphogenetic protein (PLAB) and that its upregulation by 4-HPR occurs through the activation of a signaling cascade starting from increase of ROS generation, leading to induction of endoplasmic reticulum (ER) stress response and Jun N-terminal Kinase (JNK) activation [9], [10].