CD5 and B-cell chronic lymphocytic leukemia: In addition, distinguishing a primary diffuse large B-cell lymphoma (DLBCL) from a secondary DLBCL arising from SLL/CLL can be difficult or impossible in FNA material, as well as histological material, particularly because some of these cases will also have a loss of CD5 and CD23.[33, 34] Thus, our study does not adequately represent the transformations to a large cell NHL.