The Actg1-floxed Atoh1-cre mice were characterized on the C57Bl/6 inbred genetic background, which is predisposed to progressive hearing loss by the age-related hearing loss (AHL) susceptible allele of the cadherin23 gene (Cdh23ahl) [25]. This evidence concerns the gene ATOH1 and acute hemorrhagic leukoencephalitis.