The source of the CXCL8 and PGE2 should be the pancreatic tumor microenvironment itself as very high levels of both CXCL8 and COX-2 are expressed at this site [54], [55] especially by the fibrotic stroma surrounding the tumor nests (Tjomsland et al work in progress). Here, CXCL8 is linked to neoplasm.